PillRx only · Insert · Vaginal
Estradiol
Brands: Imvexxy · Vagifem · Estradiol
5 ACTIVE SUPPLIERS — US
openFDA · updated weekly
US9 NDCs
5 active makers
5 active makers
UKComing
soon
soon
CAComing
soon
soon
AUComing
soon
soon
EUComing
soon
soon
US acquisition costNADAC · per unit
Average across 8 priced NDCs. A benchmark of pharmacy acquisition cost — not a retail quote.
$20.103
Latest avg · Jul 22, 2026
+2%
Since Dec 17, 2025
5
Active US suppliers
60%
Top-2 supplier share*
Medicaid dispensing volumeSDUD · per quarter
Prescriptions dispensed under Medicaid (fee-for-service + managed care), summed nationally. The closest free proxy to sales volume — Medicaid only, not all-payer.
12K
Rx · 2026 Q1
168K
Units dispensed
-12%
Rx vs. year ago
5
Quarters · since 2025 Q1
Who makes it5 active · 0 exited
US labelers as registered with FDA. Repackagers relabel another company's product; share* is of listed packages, not sales.
| Labeler | Type | Packages | Status |
|---|---|---|---|
| Mayne Pharma Inc. | unknown | 6 | SUPPLYING |
| Novo Nordisk | unknown | 3 | SUPPLYING |
| Bryant Ranch Prepack | repackager | 2 | SUPPLYING |
| Teva Pharmaceuticals USA, Inc. | unknown | 2 | SUPPLYING |
| Amneal Pharmaceuticals of New York LLC | unknown | 2 | SUPPLYING |
Regulatory & supply eventsFDA · US
Shortages, recalls, and registration changes attached to this drug concept.
- Mar 19, 2018RECALLRecall (Class II): Estradiol Vaginal Inserts, USP 10 mcg, packaged in a) 8 inserts/carton (NDC 0093-3223-08) and b) 18 inserts/carton (NDC…
Defective Container: This recall is being initiated due to product complaints regarding difficulty in dispensing the tablet from the applicator. — Recalling firm: Teva Pharmaceuticals USA — Distributed within the United States and Puerto Rico.